Objective: Aortic valve (AV) leaflets rely on a precise extracellular matrix (ECM) microarchitecture for appropriate biomechanical performance.The ECM structure is maintained by valvular interstitial cells (VICs), which reside within the leaflets.The presence of pigment produced by a melanocytic population of VICs in mice with dark coats has been g
Although sciatica is commonly associated with lumbar spinal issues, it Diecast Truck is important to acknowledge that non-spinal factors can also play a significant role in this condition.This is particularly relevant for female patients, in whom gynecologic conditions can lead to secondary sciatic neuropathy.Herein, we report the case of a 66-year
Wildland firefighters often work in remote settings with multiple hazards that can cause life-threatening injuries.Prompt access to medical care is key to reducing injury consequences.For the last decade, Scales a spatial model of wildland firefighter estimated ground evacuation time (GET) has been used when developing operational response strategi
Abstract DNAJB6b is a molecular chaperone of the heat shock protein Pokers network, shown to play a crucial role in preventing aggregation of several disease-related intrinsically disordered proteins.Using homology modeling and microsecond-long all-atom molecular dynamics (MD) simulations, we show that monomeric DNAJB6b is a transiently interconver